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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 22:1072-1076 (6 2001)
© 2001 American Society of Neuroradiology

ARTICLE

Cerebral Amyloid Angiopathy Presenting as Nonhemorrhagic Diffuse Encephalopathy: Neuropathologic and Neuroradiologic Manifestations in One Case

Massimo Caulo^a, Donatella Tampieri^a, Roland Brassard^a, Marie Christine Guiot^a and Denis Melanson^a

^a From the Departments of Neuroradiology (M.C., D.T., R.B., D.M.) and Neuropathology (M.C.G.), Montreal Neurological Institute of McGill University, Montreal, Canada, and the Department of Radiology (M.C.), University of L'Aquila, L'Aquila, Italy.

Summary: A case of cerebral amyloid angiopathy is presented with MR imaging findings of high intense signal on T2-weighted sequences at the level of the white and gray matter of both hemispheres in the absence of neuroradiologic signs of cerebral hemorrhage. The biopsy specimen revealed deposition of amyloid in the walls of the intracranial arterial branches and focal ischemic changes and gliosis in the gray and white matter. We consider this presentation to be very unusual in patients affected by cerebral amyloid angiopathy.

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