Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sugahara, T. Articles by Takahashi, M. Search for Related Content PubMed PubMed Citation Articles by Sugahara, T. Articles by Takahashi, M.

American Journal of Neuroradiology 22:1306-1315 (8 2001)
© 2001 American Society of Neuroradiology

ARTICLE

Perfusion-sensitive MR Imaging of Gliomas: Comparison between Gradient-echo and Spin-echo Echo-planar Imaging Techniques

Takeshi Sugahara^a, Yukunori Korogi^a, Masato Kochi^a, Yukitaka Ushio^a and Mutsumasa Takahashi^a

^a From the Departments of Radiology (T.S., Y.K., M.T.) and Neurosurgery (M.K., Y.U.), Kumamoto University School of Medicine, Kumamoto, Japan.

BACKGROUND AND PURPOSE: The different sensitivities to vessel size of gradient-echo echo-planar imaging (GE-EPI) and spin-echo EPI (SE-EPI) might indicate the relative cerebral blood volumes (rCBVs) of different tumor sizes. The techniques of GE-EPI and SE-EPI were compared for detecting low- versus high-grade gliomas.

METHODS: Six patients with low-grade gliomas and 19 patients with high-grade gliomas underwent two perfusion-sensitive MR procedures, one produced by a GE- and the other by an SE-EPI technique. Maximum rCBV ratios normalized with rCBV of contralateral white matter were calculated for evaluation. P < .05 was considered statistically significant.

RESULTS: Maximum rCBV ratios of high-grade gliomas obtained with the GE-EPI technique (mean, 5.0 ± 2.9) were significantly higher than those obtained with the SE-EPI technique (mean, 2.9 ± 2.3) (P = .02). Maximum rCBV ratios of low-grade gliomas obtained with the GE-EPI technique (mean, 1.2 ± 0.7) were almost equal to those obtained with the SE-EPI technique (mean, 1.2 ± 0.6), and there was no significant difference (P = .66). The difference in the maximum rCBV ratios between the low- and high-grade gliomas reached significance when obtained with the GE-EPI technique (P = .01).

CONCLUSION: The GE-EPI technique seems more useful for detecting low- versus high-grade gliomas than the SE-EPI technique.

This article has been cited by other articles:

				L.S. Hu, L.C. Baxter, D.S. Pinnaduwage, T.L. Paine, J.P. Karis, B.G. Feuerstein, K.M. Schmainda, A.C. Dueck, J. Debbins, K.A. Smith, et al. Optimized Preload Leakage-Correction Methods to Improve the Diagnostic Accuracy of Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging in Posttreatment Gliomas AJNR Am. J. Neuroradiol., January 1, 2010; 31(1): 40 - 48. [Abstract] [Full Text] [PDF]

				G.S. Young and K. Setayesh Spin-Echo Echo-Planar Perfusion MR Imaging in the Differential Diagnosis of Solitary Enhancing Brain Lesions: Distinguishing Solitary Metastases from Primary Glioma AJNR Am. J. Neuroradiol., March 1, 2009; 30(3): 575 - 577. [Abstract] [Full Text] [PDF]

				E. L. Gasparetto, M. A. Pawlak, S. H. Patel, J. Huse, J. H. Woo, J. Krejza, M. R. Rosenfeld, D. M. O'Rourke, R. Lustig, E. R. Melhem, et al. Posttreatment Recurrence of Malignant Brain Neoplasm: Accuracy of Relative Cerebral Blood Volume Fraction in Discriminating Low from High Malignant Histologic Volume Fraction Radiology, March 1, 2009; 250(3): 887 - 896. [Abstract] [Full Text] [PDF]

				E. S. Paulson and K. M. Schmainda Comparison of Dynamic Susceptibility-weighted Contrast-enhanced MR Methods: Recommendations for Measuring Relative Cerebral Blood Volume in Brain Tumors Radiology, November 1, 2008; 249(2): 601 - 613. [Abstract] [Full Text] [PDF]

				G. B. Caseiras, J.S. Thornton, T. Yousry, C. Benton, J. Rees, A.D. Waldman, and H.R. Jager Inclusion or Exclusion of Intratumoral Vessels in Relative Cerebral Blood Volume Characterization in Low-Grade Gliomas: Does It Make a Difference? AJNR Am. J. Neuroradiol., June 1, 2008; 29(6): 1140 - 1141. [Abstract] [Full Text] [PDF]

				K. E. Emblem, B. Nedregaard, T. Nome, P. Due-Tonnessen, J. K. Hald, D. Scheie, O. C. Borota, M. Cvancarova, and A. Bjornerud Glioma Grading by Using Histogram Analysis of Blood Volume Heterogeneity from MR-derived Cerebral Blood Volume Maps Radiology, June 1, 2008; 247(3): 808 - 817. [Abstract] [Full Text] [PDF]

				N. Danchaivijitr, A. D. Waldman, D. J. Tozer, C. E. Benton, G. Brasil Caseiras, P. S. Tofts, J. H. Rees, and H. R. Jager Low-Grade Gliomas: Do Changes in rCBV Measurements at Longitudinal Perfusion-weighted MR Imaging Predict Malignant Transformation? Radiology, April 1, 2008; 247(1): 170 - 178. [Abstract] [Full Text] [PDF]

				G G Fan, Q L Deng, Z H Wu, and Q Y Guo Usefulness of diffusion/perfusion-weighted MRI in patients with non-enhancing supratentorial brain gliomas: a valuable tool to predict tumour grading? Br. J. Radiol., August 1, 2006; 79(944): 652 - 658. [Abstract] [Full Text] [PDF]

				S.J. Mills, T.A. Patankar, H.A. Haroon, D. Baleriaux, R. Swindell, and A. Jackson Do cerebral blood volume and contrast transfer coefficient predict prognosis in human glioma? AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 853 - 858. [Abstract] [Full Text] [PDF]

				J.L. Boxerman, K.M. Schmainda, and R.M. Weisskoff Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not. AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 859 - 867. [Abstract] [Full Text] [PDF]

				T. F. Patankar, H. A. Haroon, S. J. Mills, D. Baleriaux, D. L. Buckley, G. J.M. Parker, and A. Jackson Is Volume Transfer Coefficient (Ktrans) Related to Histologic Grade in Human Gliomas? AJNR Am. J. Neuroradiol., November 1, 2005; 26(10): 2455 - 2465. [Abstract] [Full Text] [PDF]

				N. Bulakbasi, M. Kocaoglu, A. Farzaliyev, C. Tayfun, T. Ucoz, and I. Somuncu Assessment of Diagnostic Accuracy of Perfusion MR Imaging in Primary and Metastatic Solitary Malignant Brain Tumors AJNR Am. J. Neuroradiol., October 1, 2005; 26(9): 2187 - 2199. [Abstract] [Full Text] [PDF]

				A Jackson Analysis of dynamic contrast enhanced MRI Br. J. Radiol., December 1, 2004; 77(suppl_2): S154 - S166. [Full Text] [PDF]

				K. M. Schmainda, S. D. Rand, A. M. Joseph, R. Lund, B. D. Ward, A. P. Pathak, J. L. Ulmer, M. A. Baddrudoja, and H. G. J. Krouwer Characterization of a First-Pass Gradient-Echo Spin-Echo Method to Predict Brain Tumor Grade and Angiogenesis AJNR Am. J. Neuroradiol., October 1, 2004; 25(9): 1524 - 1532. [Abstract] [Full Text] [PDF]

				D. J. Covarrubias, B. R. Rosen, and M. H. Lev Dynamic Magnetic Resonance Perfusion Imaging of Brain Tumors Oncologist, September 1, 2004; 9(5): 528 - 537. [Abstract] [Full Text] [PDF]

				M. H. Lev, Y. Ozsunar, J. W. Henson, A. A. Rasheed, G. D. Barest, G. R. Harsh IV, M. M. Fitzek, E. A. Chiocca, J. D. Rabinov, A. N. Csavoy, et al. Glial Tumor Grading and Outcome Prediction Using Dynamic Spin-Echo MR Susceptibility Mapping Compared with Conventional Contrast-Enhanced MR: Confounding Effect of Elevated rCBV of Oligodendroglimoas AJNR Am. J. Neuroradiol., February 1, 2004; 25(2): 214 - 221. [Abstract] [Full Text] [PDF]

				M. A. Badruddoja, H. G.J. Krouwer, S. D. Rand, K. J. Rebro, A. P. Pathak, and K. M. Schmainda Antiangiogenic effects of dexamethasone in 9L gliosarcoma assessed by MRIcerebral blood volume maps Neuro Oncology, October 1, 2003; 5(4): 235 - 243. [Abstract] [PDF]

				J U Harrer, L Mayfrank, M Mull, and C Klotzsch Second harmonic imaging: a new ultrasound technique to assess human brain tumour perfusion J. Neurol. Neurosurg. Psychiatry, March 1, 2003; 74(3): 333 - 342. [Abstract] [Full Text] [PDF]