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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 22:1386-1388 (8 2001)
© 2001 American Society of Neuroradiology

ARTICLE

Rosai-Dorfman Disease Presenting with Isolated Bilateral Orbital Masses: Report of Two Cases

Edwin Wang^a, Yoshimi Anzai^a, August Paulino^a and Jeffery Wong^a

^a From the Department of Radiology (E.W., Y.A., J.W.) and the Department of Pathology (A.P.), University of Michigan Medical Center, Ann Arbor, Michigan.

Summary: Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is a rare benign idiopathic proliferative disease of phagocytic histiocytes. Approximately 80% of patients present with painless massive cervical lymphadenopathy. Isolated extranodal involvement is relatively uncommon. Two cases of Rosai-Dorfman disease are reported: one with isolated bilateral orbital involvement and one with marked cervical lymphadenopathy and multiple dural-based and intraventricular masses.

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