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American Journal of Neuroradiology 22:1476-1479 (9 2001)
© 2001 American Society of Neuroradiology

ARTICLE

Decreased Diffusion in Central Pontine Myelinolysis

Steven C. Cramer^a, Keith C. Stegbauer^a, Alex Schneider^a, John Mukai^a and Kenneth R. Maravilla^a

^a From the Departments of Neurology (S.C.C., A.S.), Bioengineering (K.C.S.), and Radiology (K.R.M.), University of Washington, Seattle, WA, and Kennewick General Hospital (J.M.), Kennewick, WA.

Summary: Two patients with central pontine myelinolysis (CPM) were studied with diffusion-weighted MR imaging 1 week after onset of tetraplegia. In both patients, affected white matter showed hyperintensity on diffusion-weighted images associated with a decrease in apparent diffusion coefficient (ADC) values. In one patient studied serially, ADC values normalized by 3 weeks after tetraplegia. Early in the clinical course, diagnosis of CPM can sometimes be difficult. Hyperintensity on diffusion-weighted images may therefore have diagnostic utility. Decreased lesional ADC values support the notion that CPM is a consequence of relative intracellular hypotonicity.

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