Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sener, R. N. Search for Related Content PubMed PubMed Citation Articles by Sener, R. N.

American Journal of Neuroradiology 22:1587-1589 (9 2001)
© 2001 American Society of Neuroradiology

ARTICLE

Demonstration of Glycine Peaks at 3.50 ppm in a Patient with van der Knaap Syndrome

R. Nuri Sener^a

^a From the Department of Radiology, Ege University Hospital, Bornova, Izmir, 35100, Turkey.

Summary: Elevated levels of glycine in the CSF have recently been documented in van der Knaap syndrome (diffuse leukoencephalopathy associated with cystic degeneration of the white matter). This report describes a patient affected with the syndrome in whom proton MR spectroscopy showed probable glycine peaks at 3.50 ppm in the brain parenchyma. An experimental study with a superconducting 9.397-T laboratory spectrometer identified the location of pure glycine at 3.52 ppm, originating from the methylene (CH₂) group of the molecule. This suggests that the peak at 3.50 ppm in patients with van der Knaap syndrome may belong to glycine, as a slight shift in peak resonances is possible as a result of spatial electron interactions.

This article has been cited by other articles:

				M. S. Van der Knaap and R. N. Sener Forget About "van der Knaap Syndrome," Forget about Glycine AJNR Am. J. Neuroradiol., May 1, 2003; 24(5): 1030 - 1030. [Full Text] [PDF]