Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gosche, K. M. Articles by Snowdon, D. A. Search for Related Content PubMed PubMed Citation Articles by Gosche, K. M. Articles by Snowdon, D. A.

American Journal of Neuroradiology 22:1686-1689 (October 2001)
© 2001 American Society of Neuroradiology

ARTICLE

An Automated Technique for Measuring Hippocampal Volumes from MR Imaging Studies

Karen M. Gosche^a, James A. Mortimer^a, Charles D. Smith^a, William R. Markesbery^a and David A. Snowdon^a

^a From the Institute on Aging (K.M.G., J.A.M.), University of South Florida, Tampa; and the Departments of Neurology (C.D.S.), Pathology and Neurology (W.R.M.), and Preventive Medicine (D.A.S.), College of Medicine, University of Kentucky, Lexington.

Summary: We describe an automated volumetric measure of the hippocampus obtained with software called the Knowledge-Guided MRI Analysis Program (KGMAP). Postmortem MR images from 56 participants in the Nun Study were used to validate the measure. KGMAP-determined volumes strongly correlated with those obtained with manual tracings and neurofibrillary pathologic findings of Alzheimer disease in the hippocampus. KGMAP provides a rapid and accurate estimate of hippocampal volume that is suitable for use in clinical practice.

This article has been cited by other articles:

				B. H. Ridha, J. Barnes, L. A. van de Pol, J. M. Schott, R. G. Boyes, M. M. Siddique, M. N. Rossor, P. Scheltens, and N. C. Fox Application of Automated Medial Temporal Lobe Atrophy Scale to Alzheimer Disease Arch Neurol, June 1, 2007; 64(6): 849 - 854. [Abstract] [Full Text] [PDF]

				J. A. Mortimer, A. R. Borenstein, K. M. Gosche, and D. A. Snowdon Very Early Detection of Alzheimer Neuropathology and the Role of Brain Reserve in Modifying Its Clinical Expression J Geriatr Psychiatry Neurol, December 1, 2005; 18(4): 218 - 223. [Abstract] [PDF]

				J. A. Mortimer, K. M. Gosche, K. P. Riley, W. R. Markesbery, and D. A. Snowdon Delayed recall, hippocampal volume and Alzheimer neuropathology: Findings from the Nun Study Neurology, February 10, 2004; 62(3): 428 - 432. [Abstract] [Full Text] [PDF]

				K. M. Gosche, J. A. Mortimer, C. D. Smith, W. R. Markesbery, and D. A. Snowdon Hippocampal volume as an index of Alzheimer neuropathology: Findings from the Nun Study Neurology, May 28, 2002; 58(10): 1476 - 1482. [Abstract] [Full Text] [PDF]