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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 22:1764-1767 (October 2001)
© 2001 American Society of Neuroradiology

ARTICLE

Use of Abciximab for Mediation of Thromboembolic Complications of Endovascular Therapy

Harry J. Cloft^a, Owen B. Samuels^a, Frank C. Tong^a and Jacques E. Dion^a

^a From the Departments of Radiology (H.J.C., F.C.T., J.E.D.) and Neurosurgery (H.J.C., O.B.S., J.E.D.), Emory University Hospital, Atlanta, GA.

Summary: We describe four cases in which abciximab was used as a thrombolytic rescue agent in the setting of thrombotic events complicating interventional neuroradiologic procedures. After IV administration of abciximab, the thrombus resolved within 30 min in three cases, whereas no thrombolysis occurred in the fourth case despite the addition of intraarterial tissue plasminogen activator. Further evaluation of glycoprotein IIb-IIIa inhibitors in patients with cerebral thromboembolic events is necessary to prove clinical efficacy.

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