American Journal of Neuroradiology 23:1747-1756, November-December 2002
© 2002 American Society of Neuroradiology
BRAIN
The Substantia Nigra in Parkinson Disease: Proton Density-Weighted Spin-Echo and Fast Short Inversion Time Inversion-Recovery MR Findings
* Department of Radiology, Iwate Medical University, Uchimaru, Morioka, Japan
High Field Magnetic Resonance Imaging Research Institute, Iwate Medical University, Uchimaru, Morioka, Japan
Department of Neuroanatomy, Iwate Medical University, Uchimaru, Morioka, Japan
Address reprint requests to Hirobumi Oikawa, MD, Department of Radiology, Iwate Medical University School of Medicine, 19–1 Uchimaru, Morioka 020-8505, Japan
BACKGROUND AND PURPOSE: A reduction in the area of the substantia nigra (SN) has been shown in patients with Parkinson disease. The substantia nigra is anteroinferolateral to the red nucleus, and it is important to precisely locate its true anatomic location to accurately measure SN area. Our purpose was to determine the exact location of the substantia nigra by correlating imaging and anatomic findings. We also attempted to quantitate SN area in patients with Parkinson disease compared with that in healthy control subjects on the basis of proton density-weighted spin-echo (SE) and fast short inversion time inversion-recovery (STIR) MR imaging findings.
METHODS: In four healthy volunteers, dual-echo SE and fast STIR MR images were obtained in three orthogonal planes and an oblique coronal plane. These images were correlated with anatomic specimens to determine the location of the SN. The area of the SN was also measured on oblique coronal fast STIR images obtained at a plane perpendicular to the SN in 22 patients with Parkinson disease and in 22 age- and sex-matched healthy volunteers.
RESULTS: The true anatomic location of the SN, anteroinferolateral to the red nucleus, was accurately identified, not on T2-weighted images, but on proton density-weighted SE images and fast STIR images as an area of hyperintense gray matter. The hypointense area seen on T2-weighted images corresponded to the anterosuperior aspect of the SN and to the adjacent crus cerebri. No statistically significant differences were noted in the size of the SN when the oblique coronal images of patients with Parkinson disease were compared with those of the control groups.
CONCLUSION: The SN is located mainly beneath the red nucleus. Its location cannot be determined on the basis of T2-weighted imaging results but rather on the basis of proton density-weighted SE or fast STIR findings. SN volume loss is not found in Parkinson disease, and this finding is compatible with that of recent pathology reports in the literature.
This article has been cited by other articles:
 |
|
 |
|
  D. E. Vaillancourt, M. B. Spraker, J. Prodoehl, I. Abraham, D. M. Corcos, X. J. Zhou, C. L. Comella, and D. M. Little High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease Neurology, April 21, 2009; 72(16): 1378 - 1384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Adachi, H. Kabasawa, and E. Kawaguchi Depiction of the Cranial Nerves Within the Brain Stem with Use of PROPELLER Multishot Diffusion-Weighted Imaging AJNR Am. J. Neuroradiol., May 1, 2008; 29(5): 911 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. W. Martin, M. Wieler, and M. Gee Midbrain iron content in early Parkinson disease: A potential biomarker of disease status Neurology, April 15, 2008; 70(16_Part_2): 1411 - 1417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D'Ardenne, S. M. McClure, L. E. Nystrom, and J. D. Cohen BOLD Responses Reflecting Dopaminergic Signals in the Human Ventral Tegmental Area Science, February 29, 2008; 319(5867): 1264 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L-L Chan, H Rumpel, K Yap, E Lee, H-V Loo, G-L Ho, S Fook-Chong, Y Yuen, and E-K Tan Case control study of diffusion tensor imaging in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, December 1, 2007; 78(12): 1383 - 1386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Minati, M. Grisoli, F. Carella, T. De Simone, M.G. Bruzzone, and M. Savoiardo Imaging Degeneration of the Substantia Nigra in Parkinson Disease with Inversion-Recovery MR Imaging AJNR Am. J. Neuroradiol., February 1, 2007; 28(2): 309 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Jahanshahi, C. R. G. Jones, G. Dirnberger, and C. D. Frith The Substantia Nigra Pars Compacta and Temporal Processing. J. Neurosci., November 22, 2006; 26(47): 12266 - 12273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Adachi, S. Kawakatsu, T. Hosoya, K. Otani, T. Honma, A. Shibata, and Y. Sugai Morphology of the Inner Structure of the Hippocampal Formation in Alzheimer Disease AJNR Am. J. Neuroradiol., September 1, 2003; 24(8): 1575 - 1581. [Abstract] [Full Text] [PDF]
|
|