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American Journal of Neuroradiology 23:225-230, February 2002
© 2002 American Society of Neuroradiology

Technical Note
BRAIN

Effects of Physiologic Human Brain Motion on Proton Spectroscopy: Quantitative Analysis and Correction with Cardiac Gating

Pradip M. Pattanya, Imad H. Khamisb, Brian C. Bowena, Karl Goodkinb, R. Gregory Weaverc, James B. Murdochc, M. Judith Donovan Posta and Robert M. Quencera

a Department of Radiology, University of Miami School of Medicine, FL
b Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, FL
c Marconi Medical Systems, MRI Division, Highland Heights, OH

Address reprint requests to Pradip M. Pattany, PhD, Department of Radiology, MRI Center, University of Miami School of Medicine, 1115 NW 14th Street, Miami, FL 33136

Summary: Proton MR spectroscopy is a powerful noninvasive method that enables measurement of certain brain metabolites in healthy subjects and patients with diseases. A major difficulty with clinical and research applications of in vivo proton MR spectroscopy is the variability of metabolite concentrations, especially in regions with substantial physiologic motion. In our preliminary evaluation, we tested the hypothesis that physiologic brain motion leads to lower mean metabolite concentrations and higher SDs for the measured metabolite concentrations.




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P.M. Pattany, M.G. Massand, B.C. Bowen, and R.M. Quencer
Quantitative analysis of the effects of physiologic brain motion on point-resolved spectroscopy.
AJNR Am. J. Neuroradiol., May 1, 2006; 27(5): 1070 - 1073.
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Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X