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BRAIN

Angiotropic Large Cell Lymphoma with Imaging Characteristics of CNS Vasculitis

Debbie K. Songa, Nicholas M. Boulisa, Paul E. McKeeverb and Douglas J. Quintc

a Department of Neurosurgery, University of Michigan Medical Center, Ann Arbor, MI
b Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI
c Division of Neuroradiology, University of Michigan Medical Center, Ann Arbor, MI

Address reprint requests to Nicholas M. Boulis, MD, Section of Neurosurgery, Kresge III, Room 4424, 200 Zina Pitcher Place, Ann Arbor, MI 48109

Summary: This report documents a case of angiotropic large cell lymphoma (ALCL) with imaging characteristics of CNS vasculitis. A 47-year-old man was unresponsive after a 5-month progression of neurologic deterioration and intermittent fevers. MR imaging revealed multiple areas of abnormally increased T2 signal intensity in the cerebral cortex and subcortical white matter. Despite corticosteroid treatment for presumed CNS vasculitis, the patient died. Necropsy revealed a diffuse intravascular malignant mononuclear proliferation consistent with ALCL.




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