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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 23:550-556, April 2002
© 2002 American Society of Neuroradiology

Case Report
BRAIN

Emerging Patterns of Diffusion-Weighted MR Imaging in Creutzfeldt-Jakob Disease: Case Report and Review of the Literature

Yang Mao-Draayer^a, Steven P. Braff^b, Keith J. Nagle^a, William Pendlebury^c, Paul L. Penar^d and Robert E. Shapiro^a

^a Department of Neurology, College of Medicine, University of Vermont, Burlington
^b Department of Radiology, College of Medicine, University of Vermont, Burlington
^c Department of Pathology, College of Medicine, University of Vermont, Burlington
^d Department of Neurosurgery, College of Medicine, University of Vermont, Burlington

Address reprint requests to Robert E. Shapiro, MD, PhD, Given C219B, Department of Neurology, College of Medicine, University of Vermont, Burlington, VT 05405

Summary: We report the use of diffusion-weighted MR imaging in the early diagnosis and monitoring of the progression of a histopathologically proved case of sporadic Creutzfeldt-Jakob disease. Ribbon-like areas of hyperintensity in the cerebral cortex on diffusion-weighted images corresponded to the localization of periodic sharp-wave complexes on the electroencephalogram.

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