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American Journal of Neuroradiology 23:844-846, May 2002
© 2002 American Society of Neuroradiology

Case Report
BRAIN

Cortical Dysplasia Localized by [11C]Methionine Positron Emission Tomography: Case Report

Padma Vasantha Madakasiraa, Robert Simkinsa, Tanjore Narayananb, Kelly Duniganb, Raymond J. Poelstraa and Joseph Mantilb

a Wallace Kettering Neuroscience Institute, Kettering Medical Center, Kettering, OH
b Department of Nuclear Medicine & PET, Kettering Medical Center, Kettering, OH

Address reprint requests to Joseph C. Mantil, MD, PhD, Clinical Professor and Chief, Division of Nuclear Medicine, Department of Medicine, Wright State University, Director, Nuclear Medicine/Positron Emission Tomography (PET), Kettering Medical Center, Kettering, OH 45429

Summary: Numerous functional neuroimaging techniques have progressively been added to the presurgical evaluation of refractory partial epilepsies. These investigations can help confirm the origin of seizure onset previously suggested by MR imaging and electro-clinical data, provide independent prognostic information, and provide critical diagnostic value when MR imaging results are strictly normal or show multifocal abnormalities. Of the various functional neuroimaging modalities, [11C]methionine positron emission tomography for methionine uptake into seizure foci is still in the preliminary stages of investigation. A single case of medically intractable epilepsy with focal cortical dysplasia documented by [11C]methionine positron emission tomography and possible hypotheses to explain the methionine uptake into the seizure focus are described below.






Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X