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Case Report
HEAD AND NECK

Posttransplantation Lymphoproliferative Disorder of the Paranasal Sinuses Mimicking Invasive Fungal Sinusitis: Case Report

Andrew R. Gordond, Laurie A. Loevnera, Adina I. Sonnersd, William E. Bolgerb and Mariusz A. Wasikc

a Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA
b Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia, PA
c Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, PA
d the University of Pennsylvania School of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA

Address reprint requests to Laurie A. Loevner, MD, Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104

Summary: Posttransplantation lymphoproliferative disorder (PTLD) is a challenging complication associated with organ transplantation and is usually fatal if untreated. We describe the case of a transplant recipient who presented with rapidly progressive cranial nerve palsies due to PTLD that originated in the sphenoid sinus. In this case, the clinical and radiologic presentation of PTLD mimicked invasive fungal disease. Because the management of PTLD and the management of invasive fungal infection are vastly different, prompt pathologic diagnosis is required.