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American Journal of Neuroradiology 23:1404-1406, September 2002
© 2002 American Society of Neuroradiology

Case Report
BRAIN

Increased Uptake of Technetium-99m-Hexamethylpropyleneamine Oxime Related to Primary Leptomeningeal Melanoma

Takao Sagiuchia, Katsumi Ishiia, Satoshi Utsukib, Yuuji Asanoa, Shinya Tsukaharac, Shinichi Kana, Kiyotaka Fujiib and Kazushige Hayakawaa

a Department of Radiology, Kitasato University School of Medicine, Kanagawa, Japan
b Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa, Japan
c Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan

Address reprint requests to Takao Sagiuchi, MD, Department of Radiology, Kitasato University School of Medicine, 1–15-1, Kitasato, Sagamihara, Kanagawa, 228-8555, Japan

Summary: We present an autopsy case of primary leptomeningeal melanoma visualized with technetium-99m-hexamethylpropyleneamine oxime (Tc-99m-HMPAO) single photon emission CT (SPECT) of the brain. Increased uptake of Tc-99m-HMPAO coincided with leptomeningeal enhancement on MR images and with the tumor location of the autopsy findings. It was thought that Tc-99m-HMPAO could correlate closely with melanoma. Tc-99m-HMPAO SPECT clearly showed primary leptomeningeal melanoma and severe hypoperfusion induced by intracranial hypertension and tumor proliferation.




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M. K. Demir, F. V. Aker, O. Akinci, and A. Ozgultekin
Case 134: Primary Leptomeningeal Melanomatosis
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