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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 23:1424-1426, September 2002
© 2002 American Society of Neuroradiology

Case Report
PEDIATRICS

Metachromatic Leukodystrophy: Diffusion MR Imaging Findings

R. Nuri Sener^a

^a Department of Radiology, Ege University Hospital, Bornova, Izmir, Turkey

Address reprint requests to R. Nuri Sener, MD, Professor of Radiology, Department of Radiology, Ege University Hospital, Bornova, Izmir, Turkey

Summary: Herein the case of a 10-month-old boy with metachromatic leukodystrophy is reported. Diffusion MR imaging performed with an echo-planar trace sequence revealed a cytotoxic edema-like pattern (high signal intensity on b = 1000 s/mm² images and low apparent diffusion coefficient values) in the affected white matter in the absence of an ischemic condition. This finding was unchanged at a 6-month follow-up, as revealed by diffusion MR imaging. A gradient-echo diffusion sequence, reverse fast imaging in steady-state precession, revealed hyperintense changes at the corresponding regions. It is likely that the cytotoxic edematous pattern (restricted diffusion pattern) reflected restriction of mobility of the water molecules within abnormal portions of the myelin sheath, because impaired myelin breakdown and reutilization are known features of metachromatic leukodystrophy.

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