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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 24:1955-1957, November-December 2003
© 2003 American Society of Neuroradiology

Case Report
BRAIN

Acute Marchiafava-Bignami Disease: MR Findings in Two Patients

Andres Arbelaez^a, Adriana Pajon^a and Mauricio Castillo^b

^a Department of Radiology, Instituto Neurologico de Antioquia, Medellin, Colombia
^b Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC

Address correspondence to M. Castillo, Department of Radiology, CB #7510, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7510

Summary: Marchiafava-Bignami is a rare toxic disease seen mostly in chronic alcoholics that results in progressive demyelination and necrosis of the corpus callosum. The process may extend laterally into the neighboring white matter and occasionally as far as the subcortical regions. We present the MR imaging findings in two patients who presented acutely and review the features of the disease and of other acute alcohol-related disorders.

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				K. Johkura, M. Naito, and T. Naka Cortical Involvement in Marchiafava-Bignami Disease AJNR Am. J. Neuroradiol., March 1, 2005; 26(3): 670 - 673. [Abstract] [Full Text] [PDF]