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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 24:1999-2004, November-December 2003
© 2003 American Society of Neuroradiology

Case Report
BRAIN

Tanycytomas: A Newly Characterized Hypothalamic-Suprasellar and Ventricular Tumor

K.A. Lieberman^a, J.J. Wasenko^a, R. Schelper^b, A. Swarnkar^a, J.K. Chang^a and G.S. Rodziewicz^c

^a Department of Neuroradiology, State University of New York Upstate Medical University, Syracuse, New York
^b Department of Neuropathology, State University of New York Upstate Medical University, Syracuse, New York
^c Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, New York

Address reprint requests to Kristin A. Lieberman, MD, Marshfield Clinic, Department of Radiology, 1000 North Oak Ave, Marshfield, WI 54449

Summary: We report five cases of tumors occurring in three children and in two adults. The tumors had unusual histomorphology and a mixture of ependymal and piloid-like astrocytic features and a myxoid stroma similar to myxopapillary ependymomas. MR imaging in three of the cases showed aggressive, intensely enhancing partially cystic hypothalamic-suprasellar masses near midline and near the floor of the third ventricle. In the three pediatric cases, the tumor encased the circle of Willis. This newly characterized tumor, the tanycytoma, has neoplastic cells with histomorphologic and ultrastructural characteristics similar to those of the tanycyte.

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