AJDRAJNR - American Journal of Neuroradiology

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Case Report
HEAD AND NECK

Solitary Fibrous Tumor of the Hypoglossal Nerve

Ma Lourdes S. Badiona, C. C. Tchoyoson Lima, Jennifer Teoc, Peck Leong Ongb and Francis Huia

a Departments of Neuroradiology, National Neuroscience Institute, Singapore
b Neurosurgery, National Neuroscience Institute, Singapore
c Department of Pathology, Singapore General Hospital, Singapore

Address reprint requests to Dr C. C. T. Lim, National Neuroscience Institute, Irrawady Block, 11 Jalan Tan Tock Seng, Singapore 308433

Summary: We report a case of solitary fibrous tumor (SFT) causing isolated hypoglossal nerve palsy. The neuroimaging appearance of the tumor was indistinguishable from that of schwannoma or meningioma. Immunohistochemical tests demonstrated strong reactivity for CD34 but an absence of staining for S100 and epithelial membrane antigen; this profile is indicative of an SFT. SFTs are mesenchymal tumors that can affect the dura-covered segments of cranial nerves. They may be considered in the differential diagnosis of an isolated cranial nerve palsy.