American Journal of Neuroradiology 24:481-487, March 2003
© 2003 American Society of Neuroradiology
BRAIN
Correlations of Hippocampal Atrophy and Focal Low-Frequency Magnetic Activity in Alzheimer Disease: Volumetric MR Imaging-Magnetoencephalographic Study
a Center for Magnetoencephalography Dr Pérez Modrego, Universidad Complutense de Madrid (A.F., F.M., C.A., T.O.)
b Department of Neuroradiology (J.A.) Hospital Universitario San Carlos, Madrid, Spain
c Department of Geriatrics (P.G.-G.), Hospital Universitario San Carlos, Madrid, Spain
d University of Konstanz and Center for Psychiatry, Reichenau, Konstanz, Germany (C.W.)
Address reprint requests to Tomas Ortiz MD, PhD; Centro de Magnetoencefalografía Dr Pérez Modrego. Pabellón n° 8 Facultad de Medicina. Universidad Complutense de Madrid 28040, Madrid, Spain
BACKGROUND AND PURPOSE: Patients with Alzheimer disease (AD) have more low-frequency activity on conventional EEG and increased focal magnetoencephalographic (MEG) dipole density (DD) in delta and theta bands. This activity concurs with atrophy and reduced metabolic and perfusion rates, particularly in temporoparietal structures. The relationship between functional and structural measures and their conjoined capability to improve the diagnosis of AD were assessed in this study.
METHODS: Whole-head MEG recordings were obtained in 15 patients in whom the diagnosis of AD had been made and in 16 healthy control subjects during a resting condition. MR imaging volumetric data were also obtained; these included global cerebral, temporal lobe, and hippocampal volumes.
RESULTS: DD in the delta and theta bands was enhanced in the AD group compared with the healthy control subjects. Slow-wave activity differed significantly between the groups in the temporoparietal regions of both hemispheres. Left hippocampal volume was correlated with left temporal and parietal delta DD and left temporal theta DD. A combination of left hippocampal volume and left temporal theta DD enabled correct classification in 87.1% of the patients with AD or control subjects.
CONCLUSION: Results support the predominant role of temporoparietal hypofunction as defined by DD and hippocampal structural deficits shown on MR images in patients with AD. A multidisciplinary perspective of different techniques may improve our understanding of the disease and our diagnostic abilities.
This article has been cited by other articles:
 |
|
 |
|
  F. Frohlich, M. Bazhenov, and T. J. Sejnowski Pathological Effect of Homeostatic Synaptic Scaling on Network Dynamics in Diseases of the Cortex J. Neurosci., February 13, 2008; 28(7): 1709 - 1720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Lu, Y. Zuo, H. Gu, J. A. Waltz, W. Zhan, C. A. Scholl, W. Rea, Y. Yang, and E. A. Stein Synchronized delta oscillations correlate with the resting-state functional MRI signal PNAS, November 13, 2007; 104(46): 18265 - 18269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fernandez, A. Turrero, P. Zuluaga, P. Gil, F. Maestu, P. Campo, and T. Ortiz Magnetoencephalographic Parietal {delta} Dipole Density in Mild Cognitive Impairment: Preliminary Results of a Method to Estimate the Risk of Developing Alzheimer Disease. Arch Neurol, March 1, 2006; 63(3): 427 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Maestu, A Fernandez, P G Simos, M I Lopez-Ibor, P Campo, J Criado, A Rodriguez-Palancas, F Ferre, C Amo, and T Ortiz Profiles of brain magnetic activity during a memory task in patients with Alzheimer's disease and in non-demented elderly subjects, with or without depression J. Neurol. Neurosurg. Psychiatry, August 1, 2004; 75(8): 1160 - 1162. [Abstract] [Full Text] [PDF]
|
|