American Journal of Neuroradiology 24:591-596, April 2003
© 2003 American Society of Neuroradiology
INTERVENTIONAL
A Collagen-Based Coil for Embolization of Saccular Aneurysms in a New Zealand White Rabbit Model
a Department of Radiology, Mayo Clinic, Rochester, MN
2 Collagen Matrix, Inc., Franklin Lakes, NJ
b Department of Radiology, Kagawa Medical University, Kagawa, Japan
Address reprint requests to David F. Kallmes, M.D., Mayo Clinic, 200 First Street SW, Rochester, MN 55905
BACKGROUND AND PURPOSE: In the treatment of cerebral aneurysms, platinum coils often fail to elicit a fibrotic response. We tested the hypothesis that a new, collagen-based endovascular coil would improve angiographic and histologic outcomes as compared with those achieved with platinum coils in a rabbit model of saccular aneurysms.
METHODS: Elastase-induced aneurysms were created in 12 New Zealand White rabbits (body weight, 3–4 kg). Embolization was performed either by use of collagen-based coils (n = 6) or platinum coils (n = 6). In both coil groups, subjects were kept alive for either 2 weeks (n = 3 [collagen], n = 3 [platinum]) or 10 weeks (n = 3 [collagen], n = 3 [platinum]) after embolization and then were sacrificed. Digital subtraction angiography (DSA) was performed immediately after embolization and immediately before sacrifice. Postmortem histologic analysis of all coils was performed.
RESULTS: Collagen-based coils were loosely packed in all cases because of limitations in size of coils available for embolization. In all six aneurysms packed with collagen-based coils, progressive thrombosis was noted at follow-up (DSA). Platinum coil samples were densely packed in all six cases. Progressive thrombosis was seen in one case, and interval regrowth was present in one case. Two weeks after embolization, collagen-based coil samples showed a marked peri-coil cellular response. Ten weeks after embolization, collagen-based samples had dense connective tissue matrix deposition in two of three cases. Platinum coils had unorganized thrombus at 2 weeks; loose-matrix deposition was only seen in the 10-week samples. Smooth muscle actin-positive cells were seen across the neck of the aneurysm in four of six collagen-based coil cases.
CONCLUSION: Collagen-based coils show a marked cellular response in animal-model aneurysms, with resultant high rates of progressive occlusion after embolization. Dense matrix deposition is commonly seen with collagen-based coils. This contrasts with low rates of progressive thrombosis and high rates of loose matrix deposition seen with platinum coils.
This article has been cited by other articles:
 |
|
 |
|
  C.T. Whitlow, C.P. Geer, C.W.T. Mattern, B.J. Mussat-Whitlow, S.K. Yazdani, J.L. Berry, J.H. Lalli, R.O. Claus, V.R. Challa, and P.P. Morris Endovascular Histologic Effects of Ultrathin Gold- or Vitronectin-Coated Platinum Aneurysm Coils in a Rodent Arterial Occlusion Model: A Preliminary Investigation AJNR Am. J. Neuroradiol., January 1, 2009; 30(1): 85 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.A. Lewis, Y.H. Ding, D. Dai, R. Kadirvel, M.A. Danielson, H.J. Cloft, and D.F. Kallmes Morbidity and Mortality Associated with Creation of Elastase-Induced Saccular Aneurysms in a Rabbit Model AJNR Am. J. Neuroradiol., January 1, 2009; 30(1): 91 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Dai, Y.H. Ding, M.A. Danielson, R. Kadirvel, G.A. Helm, D.A. Lewis, H.J. Cloft, and D.F. Kallmes Endovascular Treatment of Experimental Aneurysms with Use of Fibroblast Transfected with Replication-Deficient Adenovirus Containing Bone Morphogenetic Protein-13 Gene AJNR Am. J. Neuroradiol., April 1, 2008; 29(4): 739 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.H. Ding, D. Dai, R. Kadirvel, D.A. Lewis, H.J. Cloft, and D.F. Kallmes Relationship Between Aneurysm Volume and Histologic Healing after Coil Embolization in Elastase-Induced Aneurysms: A Retrospective Study AJNR Am. J. Neuroradiol., January 1, 2008; 29(1): 98 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.J. Rivet, C.J. Moran, A. Mazumdar, T.K. Pilgram, C.P. Derdeyn, and D.T. Cross Single-Institution Experience with Matrix Coils in the Treatment of Intracranial Aneurysms: Comparison with Same-Center Outcomes with the Use of Platinum Coils AJNR Am. J. Neuroradiol., October 1, 2007; 28(9): 1736 - 1742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.H. Ding, D. Dai, M.A. Danielson, R. Kadirvel, D.A. Lewis, H.J. Cloft, and D.F. Kallmes Control of Aneurysm Volume by Adjusting the Position of Ligation During Creation of Elastase-Induced Aneurysms: A Prospective Study AJNR Am. J. Neuroradiol., May 1, 2007; 28(5): 857 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bendszus and L. Solymosi Cerecyte Coils in the Treatment of Intracranial Aneurysms: A Preliminary Clinical Study AJNR Am. J. Neuroradiol., November 1, 2006; 27(10): 2053 - 2057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.H. Ding, D. Dai, D.A. Lewis, M.A. Danielson, R. Kadirvel, J.N. Mandrekar, H.J. Cloft, and D.F. Kallmes Can neck size in elastase-induced aneurysms be controlled? A retrospective study. AJNR Am. J. Neuroradiol., September 1, 2006; 27(8): 1681 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.H. Ding, D. Dai, M.A. Danielson, R. Kadirvel, D.A. Lewis, H.J. Cloft, and D.F. Kallmes Intra-arterial digital subtraction angiography through the ear artery for experimental aneurysm imaging. AJNR Am. J. Neuroradiol., September 1, 2006; 27(8): 1700 - 1702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Cloft Have you been smoking something that is biologically active? AJNR Am. J. Neuroradiol., February 1, 2006; 27(2): 240 - 242. [Full Text] [PDF]
|
|
|
|
|
|
D. Dai, Y.H. Ding, D.A. Lewis, and D.F. Kallmes A Proposed Ordinal Scale for Grading Histology in Elastase-Induced, Saccular Aneurysms AJNR Am. J. Neuroradiol., January 1, 2006; 27(1): 132 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.H. Ding, D. Dai, D.A. Lewis, M.A. Danielson, R. Kadirvel, H.J. Cloft, and D.F. Kallmes Long-Term Patency of Elastase-Induced Aneurysm Model in Rabbits AJNR Am. J. Neuroradiol., January 1, 2006; 27(1): 139 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Dai, Y. H. Ding, M. A. Danielson, R. Kadirvel, D. A. Lewis, H. J. Cloft, and D. F. Kallmes Histopathologic and Immunohistochemical Comparison of Human, Rabbit, and Swine Aneurysms Embolized with Platinum Coils AJNR Am. J. Neuroradiol., November 1, 2005; 26(10): 2560 - 2568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. H. Ding, D. Dai, D. A. Lewis, M. A. Danielson, R. Kadirvel, J. N. Mandrekar, H. J. Cloft, and D. F. Kallmes Can Neck Size in Elastase-Induced Aneurysms Be Controlled? A Prospective Study AJNR Am. J. Neuroradiol., October 1, 2005; 26(9): 2364 - 2367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Miskolczi, B. Nemes, L. Cesar, O. Masanari, and M. J. Gounis Contrast Injection via the Central Artery of the Left Ear in Rabbits: A New Technique to Simplify Follow-Up Studies AJNR Am. J. Neuroradiol., September 1, 2005; 26(8): 1964 - 1966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. H. Ding, D. Dai, D. A. Lewis, H. J. Cloft, and D. F. Kallmes Angiographic and Histologic Analysis of Experimental Aneurysms Embolized with Platinum Coils, Matrix, and HydroCoil AJNR Am. J. Neuroradiol., August 1, 2005; 26(7): 1757 - 1763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Pelz, P. Lylyk, and M. Negoro Interventional Neuroradiology Stroke, February 1, 2004; 35(2): 381 - 382. [Full Text] [PDF]
|
|