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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 24:748-750, April 2003
© 2003 American Society of Neuroradiology

PEDIATRICS

Abnormalities in the Cerebral Arterial System in Osteogenesis Imperfecta

Sait Albayram^a, Osman Kizilkilic^a, Halit Yilmaz^a, Beyhan Tuysuz^b, Naci Kocer^a and Civan Islak^a

^a Department of Radiology, Division of Neuroradiology, Cerrahpasa Medical School, Istanbul University, Turkey
^b Department of Pediatrics, Division of Genetics, Cerrahpasa Medical School, Istanbul University, Turkey

Address reprint requests to Sait Albayram, Istanbul University, Cerrahpasa Medical School, Department of Radiology, Division of Neuroradiology, 34300 Kocamustafapasa-Istanbul, Turkey

Summary: A 9-year-old girl with osteogenesis imperfecta (OI) type 4 was admitted to the hospital because of choreatic movement. Cerebral angiography demonstrated bilateral symmetrical stenosis of the proximal cavernous segment of internal carotid artery, prethrombotic occlusion of the M1 segment of left middle cerebral artery, and moyamoya-like collateral vascular structure arising from the right lenticulostriate arteries. After a literature review, these findings were interpreted as vasculopathic changes secondary to vascular fragility caused by the collagen abnormality in OI.

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