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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 24:965-967, May 2003
© 2003 American Society of Neuroradiology

Case Report
BRAIN

Diffusion MR Imaging Changes Associated with Wilson Disease

R.N. Sener^a

^a From the Department of Radiology, Ege University Hospital, Bornova, Izmir, 35100, Turkey

Address reprint requests to Prof. Dr. R. Nuri Sener, Department of Radiology, Ege University Hospital, Bornova, Izmir, 35100, Turkey

Summary: We herein report the case of a patient with Wilson disease. The patient underwent echo-planar diffusion MR imaging twice, 1.5 years apart. The lesions were in the putamina and caudate nuclei. At the first examination, undertaken after onset of extrapyramidal symptoms, a restricted diffusion pattern was evident. It is likely that this corresponded to cell swelling caused by the accumulation of copper. On the images obtained 1.5 years later, an opposite pattern (an elevated diffusion pattern) was noted. It is likely that this reflected necrosis, spongiform degeneration, and demyelination, which are among the known histopathologic changes associated with Wilson disease.

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