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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 24:1177-1180, June-July 2003
© 2003 American Society of Neuroradiology

Case Report
PEDIATRIC

MR Imaging and Spectroscopy of a Tuber Cinereum Hamartoma in a Patient with Growth Hormone Deficiency and Hypogonadotropic Hypogonadism

David D. Martin^a, Uwe Seeger^b, Michael B. Ranke^a and Wolfgang Grodd^b

^a Sections for Pediatric Endocrinology, University of Tübingen, Tübingen, Germany
^b Experimental Magnetic Resonance of the Central Nervous System, University of Tübingen, Tübingen, Germany

Address reprint requests to Dr. David Martin, Section for Pediatric Endocrinology, Children’s Hospital, University of Tübingen, 72076 Tübingen, Germany

Summary: To our knowledge, this is the first report of hypogonadotropic hypogonadism, or growth hormone deficiency, in a patient without non-Pallister-Hall syndrome who had hypothalamic hamartoma diagnosed on the basis of MR imaging and MR spectroscopy findings. On short-TE proton MR spectra, the N-acetylaspartate concentration in the hamartoma was lower than that in the thalamus but similar to that in the amygdala. However, myo-inositol concentration was elevated in the hamartoma compared with that in the amygdala and thalamus. This report stresses the advantages of short-TE spectroscopy and demonstrates that regional variations in spectra should be considered when reference structures are used.