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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 24:1390-1395, August 2003
© 2003 American Society of Neuroradiology

Case Report
BRAIN

Peripheral Third Cranial Nerve Enhancement in Multiple Sclerosis

M. Tariq Bhatti^a,b, Ilona M. Schmalfuss^c, Lorna S. Williams^d and Ronald G. Quisling^c

^a Department of Ophthalmology, University of Florida College of Medicine, Gainesville, FL
^b Department of Neurology, University of Florida College of Medicine, Gainesville, FL
^c Department of Radiology, University of Florida College of Medicine, Gainesville, FL
^d Department of Radiology, JFK Medical Center, Atlantis, FL

Address correspondence to M. Tariq Bhatti, M.D., University of Florida College of Medicine, Department of Ophthalmology, Box 100284 JHMHSC, Gainesville, FL

Summary: Cranial nerve III dysfunction in multiple sclerosis (MS) is uncommon. Seven cases of isolated cranial nerve III paresis associated with MS have been reported in the English-language literature. MR imaging was obtained in five cases demonstrating lesions within the midbrain. We present the detailed clinical and MR imaging findings of a young woman with MS and an isolated, painful pupil involving complete left cranial nerve III palsy. Initial MR imaging showed isolated enhancement of the cisternal portion of the cranial nerve III, suggesting that peripheral nervous system involvement may develop as part of the disease process in some patients with MS.

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