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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 24:1501-1507, September 2003
© 2003 American Society of Neuroradiology

INTERVENTIONAL

Short-Term Changes in Cerebral Microhemodynamics after Carotid Stenting

Iain D. Wilkinson^a, Paul D. Griffiths^a, Nigel Hoggard^a, Trevor J. Cleveland^b, Peter A. Gaines^b, Sumaira Macdonald^b, Fiona McKevitt^b and Graham S. Venables^b

^a Academic Unit of Radiology, University of Sheffield, England
^b Sheffield Vascular Institute, Sheffield Teaching Hospitals, England

Address reprint requests to Dr I. D. Wilkinson, Academic Unit of Radiology, C Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield, England S10 2JF

BACKGROUND AND PURPOSE: The cerebral hemodynamic sequelae of interventions in patients with severe internal carotid artery (ICA) stenoses are not fully understood. In this study, we sought to determine the immediate changes in cerebral perfusion characteristics, determined by MR imaging in patients who have undergone unilateral transluminal angioplasty and stent placement.

METHODS: Eleven patients with symptomatic high-grade ICA stenosis underwent MR imaging within 4 hours before and within 3 hours after carotid stent placement. First-pass gadolinium-enhanced imaging of perfusion was performed by using a gradient-recalled echo-planar technique. Localized relative cerebral blood volume (rCBV) and bolus first-moment transit time (TT_FM) were calculated for different vascular territories (middle, anterior, and posterior cerebral arteries) in each hemisphere.

RESULTS: Significantly longer TT_FM (P < .005) was observed in the symptomatic territory of the middle cerebral artery before intervention. After intervention, TT_FM remained significantly longer in this territory (P < .05). However, the magnitude of the interhemispheric asymmetry had declined significantly (50–60% reduction; P < .05). No significant differences or changes in rCBV were identified between hemispheres, between images, or in areas of unilateral leptomeningeal enhancement after intervention.

CONCLUSION: MR can demonstrate short-term partial resolution of timing asymmetry in interhemispheric perfusion after angioplasty and stent insertion for severe stenosis of the ICA.

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