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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 24:1545-1547, September 2003
© 2003 American Society of Neuroradiology

INTERVENTIONAL

Hydroxyapatite Ceramics As a Particulate Embolic Material: Report of the Clinical Experience

Michiya Kubo^a, Naoya Kuwayama^a, Yutaka Hirashima^a, Akira Takaku^a, Tetsuro Ogawa^b and Shunro Endo^a

^a Department of Neurosurgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
^b New Ceramics Division, Life Care Business Headquarters, PENTAX Corporation, Tokyo, Japan

Address reprint requests to Michiya Kubo, MD, Department of Neurosurgery, Toyama Medical & Pharmaceutical University, 2630 Sugitani, Toyama City, Toyama, 930-0194, Japan

BACKGROUND AND PURPOSE: Our newly developed biocompatible embolic materials, hydroxyapatite ceramic microparticles, have good visibility during injection control and were shown to be capable of producing effective occlusion of the distal arteriocapillary bed in an experimental animal study. The purpose of this present study was to evaluate hydroxyapatite ceramic microparticles for use in human meningioma embolization.

METHODS: Thirteen patients with meningiomas underwent preoperative superselective embolization with the use of hydroxyapatite microparticles. Radiologic and histopathologic studies of the surgical specimens were performed.

RESULTS: During embolization, no microcatheter clogging was observed and angiographic devascularization was consistently obtained without unexpected proximal occlusions. Histopathologic findings showed that there was mild inflammatory response in the thrombosed lumen.

CONCLUSION: Hydroxyapatite microparticles are excellent embolic materials for the treatment of human meningioma. They have excellent biocompatibility and good injection control, which produces occlusion of the distal arteriocapillary bed.

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