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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 24:1615-1617, September 2003
© 2003 American Society of Neuroradiology

Case Report
BRAIN

MR Imaging and Diffusion-Weighted Imaging Changes in Metronidazole (Flagyl)–Induced Cerebellar Toxicity

Conor J. Heaney^a, Norbert G. Campeau^a and E. Paul Lindell^a

^a From the Department of Radiology, Mayo Clinic, Rochester, MN

Address correspondence to Dr. Norbert G. Campeau, East 2 Mayo Building, Department of Radiology, Mayo Clinic, 200 First St. SW, Rochester MN 55905

Summary: We describe a case demonstrating reversible MR imaging findings, including diffusion-weighted imaging changes in association with metronidazole (Flagyl) toxicity. The diagnosis of metronidazole toxicity was made clinically and supported by the MR imaging findings. Quantitative apparent diffusion coefficient (ADC) maps demonstrated edema with associated increased ADC values within the dentate nuclei of the cerebellum on initial imaging. Follow-up imaging performed 8 weeks after cessation of metronidazole therapy demonstrated resolution of imaging findings, including diffusion changes.

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