American Journal of Neuroradiology 24:1690-1693, September 2003
© 2003 American Society of Neuroradiology
Case Report
PEDIATRICS
Pantothenate Kinase-Associated Neurodegeneration: MR Imaging, Proton MR Spectroscopy, and Diffusion MR Imaging Findings
a From the Department of Radiology, Ege University Hospital, Bornova, Izmir, Turkey
Address reprint requests to Prof. Dr. R. Nuri Sener, Department of Radiology, Ege University Hospital, Bornova, Izmir, 35100, Turkey
Summary: We herein report the case of a 15-year-old male patient with pantothenate kinase-associated neurodegeneration. The classic "eye-of-the-tiger" appearance was initially present on the globus pallidi on T2-weighted MR images and had disappeared by the time of the 10-month follow-up examination. Fluid-attenuated inversion recovery images revealed marked hypointensity in the globus pallidi and dentate nuclei and high signal intensity changes in the deep cerebral white matter. Proton MR spectroscopy revealed markedly decreased N-acetylaspartate in the globus pallidi, associated with decreased N-acetylaspartate and increased myoinositol in the deep cerebral white matter. Diffusion MR images (b=1000 s/mm2) were negative (normal appearing) for deep cerebral white matter lesions, whereas apparent diffusion coefficient values were slightly increased (1.08–1.12 x 10-3 mm2/s), compared with the apparent diffusion coefficient values from the normal white matter regions. Apparent diffusion coefficient values in the globus pallidi were lower than those in the unaffected thalamus.
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