American Journal of Neuroradiology 24:1778-1784, October 2003
© 2003 American Society of Neuroradiology
INTERVENTIONAL
High-Concentration Ethylene-Vinyl Alcohol Copolymer and Endovascular Treatment of Experimental Aneurysms: Feasibility of Embolization without Protection Devices at the Neck
a Department of Radiology, Centre Hospitalier de l’Université de Montréal (CHUM), Notre-Dame Hospital, Montreal, Quebec, Canada
b Interventional Neuroradiology Research Laboratory, Research Center of CHUM, Montreal, Quebec, Canada
Address correspondence and reprint requests to Jean Raymond, MD, Interventional Neuroradiology Laboratory, CHUM Research Center, Notre-Dame Hospital, 1560 Sherbrooke East, Suite M-8203, Montreal, Quebec, Canada, H2 L 4M1
BACKGROUND AND PURPOSE: Coiling of intracranial aneurysms is both safe and effective but may be followed by recurrences. The purpose of this study was to assess the feasibility of endovascular treatment of aneurysms with high-concentration ethylene-vinyl alcohol copolymer (HCEVOH), without the use of protection devices at the neck.
METHODS: Wide-necked bifurcation aneurysms with a high propensity for recurrences were constructed in 22 dogs. HCEVOH embolization was performed with a dedicated high-pressure microcatheter in 12 animals. Angiographic results at 3 and 12 weeks and pathologic results at 12 weeks were compared with those of a separate group of 10 animals treated with platinum coils. We used a qualitative scoring system to grade angiographic results, neointima formation, and recanalization at the neck.
RESULTS: Intraaneurysmal HCEVOH injections could be performed without carotid emboli and without a protection device in 11 of 12 animals. Fragments detached upon traction of the microcatheters at the end of the procedure on two occasions. Immediate and late angiographic results were not significantly different between the two groups (P = .807), with a tendency for angiographic recurrences at 3 months (angiographic scores were significantly worse in both groups at 12 weeks as compared with T0 [P < .02]). A complete occlusion, including the neck, even at the cost of protrusion of material at the level of the branches, is necessary to decrease risks of recurrences. Neointima formation at the surface of the embolic agent was complete at the neck of aneurysms treated with HCEVOH. The neointimal score was significantly improved with HCEVOH as compared with coil embolization (P = .03).
CONCLUSION: HCEVOH embolization of aneurysms without neck protection is feasible. It does not, however, eliminate recurrences in an experimental wide-necked aneurysm model.
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