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American Journal of Neuroradiology 24:1834-1836, October 2003
© 2003 American Society of Neuroradiology

INTERVENTIONAL

Model of Reversible Cerebral Ischemia in a Monkey Model

Charles A. Jungreisa,b, Edwin Nemotob, Fernando Boadaa and Michael B. Horowitza,b

a Department of Radiology, University of Pittsburgh Medical Center, PA
b Department of Neurological Surgery, University of Pittsburgh Medical Center, PA

Address reprint requests to Charles A. Jungreis, MD, Department of Radiology, UPMC–Presbyterian University Hospital, 200 Lothrop Street, Pittsburgh, PA 15213

Summary: We have developed a model of reversible cerebral ischemia in a high-level nonhuman primate. By using endovascular techniques, the posterior cerebral artery is permanently occluded with coils, and the ipsilateral middle cerebral artery is temporarily occluded with a balloon. The balloon can be deflated and/or removed to reestablish flow at precise time intervals. Functional imaging of the brain can be performed during occlusion and reperfusion, since the balloon can be deflated or removed in a scanner.






Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X