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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 25:25-28, January 2004
© 2004 American Society of Neuroradiology

Case Report
PEDIATRICS

Diffusion Tensor MR Imaging Visualizes the Altered Hemispheric Fiber Connection in Callosal Dysgenesis

Seung-Koo Lee^a, Susumu Mori^b, Dong Joon Kim^a, Sei Young Kim^a, Si Yeon Kim^a and Dong Ik Kim^a

^a Department of Diagnostic Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea
^b Department of Radiology and Kennedy Krieger Institute, F. M. Kirby Research Center for Functional Brain Imaging, Johns Hopkins University School of Medicine, Baltimore, MD

Address correspondence to Dr. Seung-Koo Lee, Department of Diagnostic Radiology, Yonsei University College of Medicine, 134 Shinchondong, Seodaemungu, Seoul 120–752, Korea

Summary: We report three cases of callosal dysgenesis that were evaluated by diffusion tensor imaging and fiber tractography. In partial agenesis of corpus callosum, fiber tracts from all regions of brain converged to a partially developed small genu portion and connected to the contralateral side. In complete callosal agenesis, fibers from the hemispheres failed to cross the midline and formed thick bundles running anteroposteriorly (eg, Probst bundle). The thickness of the anterior commissure was enlarged or smaller than normal brain, and other white matter tracts were not markedly different from normal brain tissue.