AJDRAJNR - American Journal of Neuroradiology

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Erbay, S. H.
Right arrow Articles by Bhadelia, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Erbay, S. H.
Right arrow Articles by Bhadelia, R.

American Journal of Neuroradiology 25:36-38, January 2004
© 2004 American Society of Neuroradiology

Case Report
PEDIATRICS

Rapid Development of Optic Glioma in a Patient with Hybrid Phakomatosis: Neurofibromatosis Type 1 and Tuberous Sclerosis

Sami H. Erbaya, Stephen A. Oljeskia and Rafeeque Bhadeliaa

a From the Department of Radiology, New England Medical Center and Tufts University School of Medicine, Boston, MA

Address correspondence to Sami H. Erbay, MD, Department of Radiology, P.O. Box 299, New England Medical Center and Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111

Summary: Increased propensity for tumor formation in neurofibromatosis and tuberous sclerosis exists because of defective tumor-suppressor genes. Although different tumor-suppressor genes may be involved in neurofibromatosis and tuberous sclerosis, at the cellular level these genes share rather common enzymatic pathways. We believe these genetic malfunctions have resulted in a cumulative or additive effect for rapid growth of optic glioma in the following unusual case that has hybrid phakomatosis.






Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X