American Journal of Neuroradiology 25:63-68, January 2004
© 2004 American Society of Neuroradiology
Technical Note
INTERVENTIONAL
Computational Simulation of Therapeutic Parent Artery Occlusion to Treat Giant Vertebrobasilar Aneurysm
a Department of Neuroendovascular Therapy, Tohoku University Graduate School of Medicine, Shock Wave Research Center, Sendai, Japan
b Institute of Fluid Science, Tohoku University, Sendai, Japan
c Department of Neurosurgery, Tohoku University, Sendai, Japan
d Ioffe Physico-Technical Institute, Russian Academy of Sciences, St. Petersburg, Russia
Address correspondence to Dr. Tamer Hassan, Department of Neuroendovascular Therapy, Tohoku University Graduate School of Medicine, 1–1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Summary: We applied computational fluid dynamics (CFD) analysis to assess 3D digital subtraction angiography findings in a patient with a giant vertebrobasilar aneurysm to simulate and compare the consequences of left and right vertebral artery occlusion. The balloon occlusion test suggested that occlusion of the right vertebral artery is the better way to treat this patient’s aneurysm from the point of view of aneurysmal thrombosis and isolation from the circulation. The computer simulation supported this conclusion, at the same time indicating that from the point of view of pressure distribution on the wall of the aneurysm, the right vertebral occlusion may be also accompanied by an undesirable effect. A high-pressure area on the aneurysm wall in systole was revealed. This high pressure potentially could lead to subsequent aneurysmal growth, which indeed occurred, as was revealed by a follow-up examination 6 months later. This study is a good example of possible future applications of CFD in patients with cerebrovascular disease before therapeutic intervention.
This article has been cited by other articles:
 |
|
 |
|
  D A Lott, M Siegel, H R Chaudhry, and C J Prestigiacomo Computational fluid dynamic simulation to assess flow characteristics of an in vitro aneurysm model JNIS, December 1, 2009; 1(2): 100 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W S Lesley and R Rangaswamy Balloon test occlusion and endosurgical parent artery sacrifice for the evaluation and management of complex intracranial aneurysmal disease JNIS, December 1, 2009; 1(2): 112 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Boussel, V. Rayz, C. McCulloch, A. Martin, G. Acevedo-Bolton, M. Lawton, R. Higashida, W. S. Smith, W. L. Young, and D. Saloner Aneurysm Growth Occurs at Region of Low Wall Shear Stress: Patient-Specific Correlation of Hemodynamics and Growth in a Longitudinal Study Stroke, November 1, 2008; 39(11): 2997 - 3002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.A. Castro, C.M. Putman, and J.R. Cebral Computational fluid dynamics modeling of intracranial aneurysms: effects of parent artery segmentation on intra-aneurysmal hemodynamics. AJNR Am. J. Neuroradiol., September 1, 2006; 27(8): 1703 - 1709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Cebral, M. A. Castro, J. E. Burgess, R. S. Pergolizzi, M. J. Sheridan, and C. M. Putman Characterization of Cerebral Aneurysms for Assessing Risk of Rupture By Using Patient-Specific Computational Hemodynamics Models AJNR Am. J. Neuroradiol., November 1, 2005; 26(10): 2550 - 2559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-D. Jou, G. Wong, B. Dispensa, M. T. Lawton, R. T. Higashida, W. L. Young, and D. Saloner Correlation between Lumenal Geometry Changes and Hemodynamics in Fusiform Intracranial Aneurysms AJNR Am. J. Neuroradiol., October 1, 2005; 26(9): 2357 - 2363. [Abstract] [Full Text] [PDF]
|
|