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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 25:343-346, February 2004
© 2004 American Society of Neuroradiology

Case Report
PEDIATRICS

Early Prenatal MR Imaging Diagnosis of Polymicrogyria

Andrea Righini^a, Salvatore Zirpoli^c, Federica Mrakic^c, Cecilia Parazzini^a, Laura Pogliani^b and Fabio Triulzi^a

^a Department of Radiology and Neuroradiology, Istituti Clinici di Perfezionamento, Milan, Italy
^b Department of Neonatology, Istituti Clinici di Perfezionamento, Milan, Italy
^c Institute of Radiology, University of Milan, Milan, Italy

Address correspondence to Andrea Righini, MD, Radiologia e Neuroradiologia, Ospedale Buzzi—ICP, Via Castelvetro 32, 20154 Milan, Italy

Summary: The case of a 24-week-old fetus that showed features suggestive of focal cortical developmental anomaly at prenatal MR imaging is presented. The anomaly was confirmed to be polymicrogyria by 34-week prenatal and the 3-day postnatal MR imaging studies. The report demonstrates that the development of polymicrogyria can be assessed throughout different stages by prenatal MR imaging. In the case reported, the additional presence of periventricular heterotopia strongly suggests that a neuronal migration alteration coexisted with a postmigrational disorder.

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