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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 25:377-381, March 2004
© 2004 American Society of Neuroradiology

Technical Note
BRAIN

Quantitative Assessment of Parenchymal and Ventricular Readjustment to Intracranial Pressure Relief

Christoph Preul^a,b, Marc Tittgemeyer^a, Dirk Lindner^b, Christos Trantakis^b and Jürgen Meixensberger^b

^a Max-Planck-Institute of Human Cognitive and Brain Science, Leipzig, Germany
^b Klinik und Poliklinik für Neurochirurgie der Universität Leipzig, Leipzig, Germany

Address reprint requests to Christoph Preul, MD, Max-Planck-Institute of Human Cognitive and Brain Sciences, Stephenstrasse 1a, 04103 Leipzig, Germany

Summary: A 26-year-old patient underwent endoscopic third ventriculostomy for the treatment of obstructive hydrocephalus. 3D volume data sets were obtained at 3 T before surgery and three times after surgery. Off-line analysis of individual imaging data (initial linear registration, intensity adjustment, and final nonlinear registration of pre- to postoperative MR images) yielded 3D displacement fields representing the postoperative structural brain change. In principle, such an analysis technique can be used in any clinical follow-up for which careful observation of tissue readjustment is of particular importance.