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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 25:614-617, April 2004
© 2004 American Society of Neuroradiology

Case Report
INTERVENTIONAL

Endovascular Management of a Mandibular Arteriovenous Malformation in a Patient with Severe Hemophilia A

Goetz Benndorf^a, Doris M. Kim^b, Horst Menneking^b and Martin Klein^b

^a Department of Radiology, Virchow Hospital, Charité, Humboldt University, Berlin, Germany
^b Department of Maxillofacial Surgery, Virchow Hospital, Charité, Humboldt University, Berlin, Germany

Address correspondence to Goetz Benndorf, MD, PhD, Department of Radiology, Baylor College of Medicine, The Methodist Hospital, One Baylor Plaza, Houston, TX 77030

Summary: The unusual case of a mandibular arteriovenous malformation in a patient with severe hemophilia A and hepatitis C is reported. Supplementary substitution of various coagulation factors allowed direct puncture and intralesional injection of a liquid adhesive, resulting in complete anatomic and clinical cure without peri- or postoperative bleeding. Replacement therapy providing normal levels of relevant coagulation factors enables endovascular treatment in a safe and effective manner in hemophiliac patients.