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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 25:746-755, May 2004
© 2004 American Society of Neuroradiology

BRAIN

Comparison of Cerebral Blood Volume and Vascular Permeability from Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging with Glioma Grade

Meng Law^a, Stanley Yang^a, James S. Babb^a,d, Edmond A. Knopp^a,b, John G. Golfinos^b, David Zagzag^c and Glyn Johnson^a

^a Department of Radiology, NYU Medical Center, NY
^b Department of Neurosurgery, NYU Medical Center, NY
^c Department of Pathology, NYU Medical Center, NY
^d Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, PA

Address reprint requests to Meng Law, MD, Department of Radiology, NYU Medical Center, MRI Dept, Schwartz Building, Basement HCC, 530 First Avenue, New York, NY 10016

BACKGROUND AND PURPOSE: Relative cerebral blood volume (rCBV) and vascular permeability (K^trans) permit in vivo assessment of glioma microvasculature. We assessed the associations between rCBV and K^trans derived from dynamic, susceptibility-weighted, contrast-enhanced (DSC) MR imaging and tumor grade and between rCBV and K^trans.

METHODS: Seventy-three patients with primary gliomas underwent conventional and DSC MR imaging. rCBVs were obtained from regions of maximal abnormality for each lesion on rCBV color maps. K^trans was derived from a pharmacokinetic modeling algorithm. Histopathologic grade was compared with rCBV and K^trans (Tukey honestly significant difference). Spearman and Pearson correlation factors were determined between rCBV, K^trans, and tumor grade. The diagnostic utility of rCBV and K^trans in discriminating grade II or III tumors from grade I tumors was assessed by logistic regression.

RESULTS: rCBV was significantly different for all three grades (P .0005). K^trans was significantly different between grade I and grade II or III (P = .027) but not between other grades or combinations of grades. Spearman rank and Pearson correlations, respectively, were as follows: rCBV and grade, r = 0.817 and r = 0.771; K^trans and grade, r = 0.234 and r = 0.277; and rCBV and K^trans, r = 0.266 and r = 0.163. Only rCBV was significantly predictive of high-grade gliomas (P < .0001).

CONCLUSION: rCBV with strongly correlated with tumor grade; the correlation between K^trans and tumor grade was weaker. rCBV and K^trans were positively but weakly correlated, suggesting that these parameters demonstrate different tumor characteristics. rCBV is a more significant predictor of high-grade glioma than K^trans.