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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 25:1049-1057, June-July 2004
© 2004 American Society of Neuroradiology

INTERVENTIONAL

Hemodynamic versus Hydrodynamic Effects of Guglielmi Detachable Coils on Intra-Aneurysmal Pressure and Flow at Varying Pulse Rate and Systemic Pressure

Angelika Sorteberg^b, Wilhelm Sorteberg^b, Beverly D. L. Aagaard^a, Alan Rappe^a and Charles M. Strother^a

^a Department of Radiology, University of Wisconsin Health Sciences Center, Madison
^b Department of Neurosurgery, Rikshospitalet, the National Hospital, Oslo, Norway

Address reprint requests to Angelika Sorteberg MD, PhD, Department of Neurosurgery, Rikshospitalet, the National Hospital, 0027 Oslo, Norway

BACKGROUND AND PURPOSE: Alterations in intra-aneurysmal pressure and flow have been observed after treatment with Guglielmi detachable coils (GDCs). We wished to determine whether these changes could be assigned to a hydrodynamic effect of the coils themselves or a compound effect of coils plus thrombus formation.

METHODS: Intra-aneurysmal pressure and flow were measured with a 0.014-inch guidewire- mounted transducer in a canine aneurysm in vivo and in vitro before and after treatment with GDCs. Flow was evaluated by using the thermodilution technique. Pressure and flow were also recorded in a bifurcational silicone aneurysm mounted onto a flow phantom during variations in systemic pressure and pulse rate before and following the insertion of GDCs.

RESULTS: The insertion of GDCs induced a reduction in flow that was qualitatively similar when the aneurysm was perfused either by blood (in vivo) or with normal saline (in vitro). Quantitatively, however, flow was reduced less distinctly during perfusion with saline. In the silicone aneurysm, pressure was inversely related to pulse rate and increased with augmenting systemic pressure, whereas flow remained constant regardless of variations in pressure and pulse rate. After GDC placement, reduced flow was dependent on pulse rate but independent of systemic pressure.

CONCLUSION: GDCs significantly reduced flow even in the absence of thrombus, indicating that they have a purely hydrodynamic effect. In the silicone model, the decrease in intra-aneurysmal flow after coiling relied upon the pulse rate in a manner suggesting the presence of resonance phenomena.

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