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American Journal of Neuroradiology 25:964-968, June-July 2004
© 2004 American Society of Neuroradiology

Case Report
BRAIN

Acute Korsakoff Syndrome Following Mammillothalamic Tract Infarction

Yuichiro Yoneoka^a,b, Norio Takeda^a, Akira Inoue^a, Yasuo Ibuchi^a, Takashi Kumagai^a, Tsutomu Sugai^a, Ken-ichiro Takeda^a and Kaoru Ueda^a

^a Departments of Neurosurgery and Emergency Medicine, Yamagata Prefecture Central Hospital, Yamagata, Japan
^b Department of Clinical Neurology and Neurosurgery, Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan

Address correspondence to Yuichiro Yoneoka, MD, PhD, Department of Functional Neurology and Neurosurgery, Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1–757 Asahi-machi, Niigata, 951-8585, Japan

Summary: There are limited case reports of structural lesions causing Korsakoff syndrome. This report describes acute Korsakoff syndrome following localized, bilateral infarction of the mammillothalamic tracts (MTTs). Axial T2-weighted imaging revealed the lesions at the lateral wall level of the third ventricle and diffusion-weighted imaging confirmed that the left lesion was new and the right old. Korsakoff syndrome persisted 6 months after the onset. This case suggests that bilateral MTT dysfunction can lead to Korsakoff syndrome.

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