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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 25:1144-1146, August 2004
© 2004 American Society of Neuroradiology

INTERVENTIONAL

Intralesional Bleomycin Injections for the Palliation of Epistaxis in Hereditary Hemorrhagic Telangiectasia

Ian C. Duncan^a and Leon Van Der Nest^b

^a Unitas Interventional Unit, Centurion, South Africa
^b Olivedale Clinic, Randburg, South Africa

Address reprint requests to Ian C. Duncan, Unitas Interventional Unit, PO Box 14031, Lyttelton, 0140, South Africa

Summary: Epistaxis is a common complication in patients with hereditary hemorrhagic telangiectasia. Its treatment is generally aimed at controlling the frequency and severity of nasal hemorrhage and involves surgery, transcatheter embolization, topical treatment, or a combination. Despite this multitude of treatment methods, the long-term prognosis for many patients remains poor. We describe a patient in whom direct intralesional injections of bleomycin successfully palliated severe recurrent epistaxis for almost 2 years without the need for adjuvant therapy.