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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 25:1242-1246, August 2004
© 2004 American Society of Neuroradiology

Case Report
BRAIN

Decreases of Blood Oxygenation Level—Dependent Signal in the Activated Motor Cortex during Functional Recovery after Resection of a Glioma

Yoshihiro Murata^a, Kaoru Sakatani^a,b, Yoichi Katayama^a, Norio Fujiwara^a, Tatsuya Hoshino^a, Chikashi Fukaya^a,c and Takamitsu Yamamoto^a,c

^a Department of Neurosurgery, Nihon University School of Medicine, Tokyo, Japan
^b Divisions of Optical Brain Engineering, Nihon University School of Medicine, Tokyo, Japan
^c Applied System Neuroscience, Nihon University School of Medicine, Tokyo, Japan

Address correspondence and reprint requests to Kaoru Sakatani, Department of Neurosurgery, Nihon University School of Medicine, 30—1, Oyaguchi-Kamimachi, Itabashi-ku, Tokyo 173, Japan

Summary: The present case demonstrates that the blood oxygenation level—dependent (BOLD) signal intensity can decrease in the activated motor cortex on the lesion side (left) of a patient with a left frontal glioma during functional recovery after surgery. Near-infrared spectroscopy revealed that the decrease of BOLD signal was associated with increases of cerebral blood volume and deoxyhemoglobin concentrations in the cerebral vessels. This implies that the interpretation of results obtained by functional MR imaging in patients with brain disorders must take into consideration such atypically evoked cerebral blood oxygenation changes, which do not increase the BOLD signals.

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