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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 25:1366-1367, September 2004
© 2004 American Society of Neuroradiology

Case Report
BRAIN

Multiple Cerebral Aneurysms and Subarachnoid Hemorrhage in a Patient with Alagille Syndrome

Hans-Georg Schlosser^a, Thoralf Kerner^b, Christian Woiciechowsky^a and Goetz Benndorf^c

^a Department of Neurosurgery, Charité, Virchow-Clinic, Humboldt-University of Berlin, Berlin, Germany
^b Department of Anesthesiology and Critical Care Medicine, Charité, Virchow-Clinic, Humboldt-University of Berlin, Berlin, Germany
^c the Department of Radiology, Baylor College of Medicine, the Methodist Hospital, Houston, TX

Address correspondence to Goetz Benndorf, MD, PhD, Department of Radiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030

Summary: Although intracranial hemorrhage has frequently been found responsible for mortality in adult patients with Alagille syndrome (AGS), no specific underlying cause has been identified. We describe the case of severe subarachnoid hemorrhage in a 30-year-old woman harboring five intracranial aneurysms and multiple peripheral vascular anomalies. To evaluate a possible higher incidence of intracranial aneurysms, a study of the cerebral vasculature in all AGS patients by using noninvasive imaging techniques should be considered.