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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 25:1457-1462, October 2004
© 2004 American Society of Neuroradiology

INTERVENTIONAL

Intratumoral Injection of Cyanoacrylate Glue in Head and Neck Paragangliomas

Daniel Giansante Abud^a, Charbel Mounayer^a, Goetz Benndorf^a, Michel Piotin^a, Laurent Spelle^a and Jacques Moret^a

^a From the Department of Interventional Neuroradiology, Foundation Rothschild, Paris, France

Address reprint requests to Jacques Moret, MD, Service de Neuroradiologie Interventionnelle, Hôpital de la Fondation Rothschild, 25–29 rue Manin 75940 Paris Cedex 19, France

BACKGROUND AND PURPOSE: Substantial intraoperative bleeding during surgical removal of head and neck paragangliomas may be a major problem in the management of these highly vascularized tumors. Traditional preoperative embolization via a transarterial approach has proved beneficial but is often limited by complex vascular anatomy and unfavorable locations. We report our experience with the preoperative devascularization of head and neck paragangliomas by using direct puncture and an intralesional injection of cyanoacrylate.

METHODS: We retrospectively analyzed nine consecutive patients with head and neck paragangliomas who were referred for preoperative devascularization. Three patients were treated for carotid-body tumors; two for vagal lesions; and four, for jugular paragangliomas. Direct puncture of the lesion was performed by using roadmap fluoroscopic guidance. Acrylic glue was injected by using continuous biplane fluoroscopy. All patients underwent postembolization control angiography and immediate postoperative CT scanning.

RESULTS: Angiograms showed that complete devascularization was achieved in all cervical glomus tumors, whereas subtotal devascularization was achieved in jugular paragangliomas. In this latter location, the injection of acrylic glue was limited by the potential risk of reflux into normal brain territory via feeders from the internal carotid or vertebral artery. The tumors were surgically removed and histologically examined. No technical or clinical complications related to the embolization procedure occurred.

CONCLUSION: Percutaneous puncture of paragangliomas in the head and neck region and their preoperative devascularization by intralesional injection of acrylic glue is a feasible, safe, and effective technique.

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