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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 25:1516-1523, October 2004
© 2004 American Society of Neuroradiology

BRAIN

Is the Subthalamic Nucleus Hypointense on T2-Weighted Images? A Correlation Study Using MR Imaging and Stereotactic Atlas Data

Didier Dormont^a,b, Kenneth G. Ricciardi^a, Dominique Tandé^e, Karine Parain^e, Carole Menuel^b, Damien Galanaud^a, Soledad Navarro^c, Philippe Cornu^c, Yves Agid^d and Jérôme Yelnik^e

^a Department of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France
^b Department of UPR 640 CNRS LENA, Pitié-Salpêtrière Hospital, Paris, France
^c Department of Neurosurgery, Pitié-Salpêtrière Hospital, Paris, France
^d Department of Neurology, Pitié-Salpêtrière Hospital, Paris, France
^e Department of INSERM U289, Pitié-Salpêtrière Hospital, Paris, France

Address reprint requests to Didier Dormont, Department of Neuroradiology and UPR 640 CNRS LENA, Pitié-Salpêtrière Hospital, 47 bd de l’Hôpital, 75651, Paris, Cedex 13, France

BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson’s disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus.

METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson’s disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content.

RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20–80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels.

CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson’s disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.

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