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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 25:1533-1537, October 2004
© 2004 American Society of Neuroradiology

Case Report
BRAIN

Glioblastoma Multiforme Causing Calvarial Destruction: An Unusual Manifestation Revisited

Vinay Gheyi^a, Ferdinand K. Hui^c, Egon M. Doppenberg^b, William Todd^d and William C. Broaddus^b

^a Department of Radiology, Medical College of Virginia, Richmond, VA
^b Department of Neurosurgery, Medical College of Virginia, Richmond, VA
^c Hunter Holmes McGuire Dept of Veteran’s Affairs, and the Department of Radiology, Medical College of Virginia, Richmond, VA
^d Department of Pathology, Medical College of Virginia, Richmond, VA

Address reprint requests to Vinay Gheyi, MD, Department of Radiology, Hunter Holmes McGuire Dept of Veteran’s Affairs, 1201 Broad Rock Blvd., Richmond, VA 23249

Summary: This report describes invasion of overlying calvaria and soft tissues by a high-grade glioma without macroscopic evidence of dural involvement. The initial radiologic examinations demonstrated a heterogeneous mass in the right frontoparietal region with both extra- and intra-axial components. Inward displacement of the adjacent dura initially prompted consideration for extra-axial lesions such as metastatic lesions, lymphoma, or an aggressive meningioma. The pathologic findings demonstrated a glial cell origin.