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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 26:61-64, January 2005
© 2005 American Society of Neuroradiology

Case Report
PEDIATRICS

Malformations of Cortical Development: High-Resolution MR and Diffusion Tensor Imaging of Fiber Tracts at 3T

C. C. Tchoyoson Lim^a, Hong Yin^a, Ngai Kun Loh^b, Violet G. E. Chua^a, Francis Hui^a and A. James Barkovich^c

^a Department of Neuroradiology, National Neuroscience Institute, Singapore
^b Department of Neurology, National Neuroscience Institute, Singapore
^c Department of Neuroradiology, University of California at San Francisco, San Francisco, CA

Address correspondence to C. C. T. Lim, MD, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433

Summary: Patients with malformations of cortical development and epilepsy may have a variety of abnormal brain findings, including abnormal gyral patterns, cortical thickening, decreased volume of white matter, and increased diffusion of white matter. The status of individual white matter fiber tracts, however, is unknown. We present a case of bilateral frontal schizencephaly and subcortical heterotopia and illustrate alterations of white matter fascicles by combined structural and functional diffusion tensor imaging at 3 T.

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