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American Journal of Neuroradiology 26:274-278, February 2005
© 2005 American Society of Neuroradiology

Case Report
BRAIN

Differential Chemosensitivity of Tumor Components in a Malignant Oligodendroglioma: Assessment with Diffusion-Weighted, Perfusion-Weighted, and Serial Volumetric MR Imaging

Hans Rolf Jägera,b, Adam D Waldmana,c, Christopher Bentona, Nicholas Foxa and Jeremy Reesa

a Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
b Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
c Department of Imaging, Charing Cross Hospital, London, United Kingdom

Address correspondence to Hans Rolf Jäger, Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom WC1N 3BG

Summary: We report the case of malignant oligodendroglioma in a 36-year-old man who underwent diffusion-weighted, perfusion-weighted, and volumetric MR imaging before and after PCV (procarbazine, CCNU, vincristine) chemotherapy. The tumor regions exhibiting a low apparent diffusion coefficient and increased relative cerebral blood volume showed a marked response to chemotherapy and dramatic decrease in volume, whereas the remaining tumor regions showed little change. Diffusion-weighted and perfusion-weighted MR imaging may be helpful in predicting chemosensitivity of glial tumors.




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Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X