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American Journal of Neuroradiology 26:347-351, February 2005
© 2005 American Society of Neuroradiology

Case Report
BRAIN

Cerebral Cortical and White Matter Lesions in Chronic Hepatic Encephalopathy: MR-Pathologic Correlations

Eiji Matsusuea,b, Toshibumi Kinoshitaa, Eisaku Ohamab and Toshihide Ogawaa

a Division of Radiology, Department of Pathophysiological and Therapeutic Science , Faculty of Medicine, Tottori University, Yonago, Japan
b Department of Neuropathology, Institute of Neurological Sciences , Faculty of Medicine, Tottori University, Yonago, Japan

Address correspondence to Eiji Matsusue, MD, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, Tottori 683-8504, Japan

Summary: We correlated MR images with histologic findings in two autopsy-proven cases of chronic hepatic encephalopathy. Cortical hyperintensities on T2-weighted images histologically revealed pseudolaminar spongy degeneration in the deep layers of the cerebral cortices and hyperintensities in the cerebral white matters showed tissue rarefaction associated with loss of myelin and axons but without reactive astrocytosis. Both lesions were considered to be caused by chronic hepatic encephalopathy.




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