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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 26:670-673, March 2005
© 2005 American Society of Neuroradiology

Case Report
BRAIN

Cortical Involvement in Marchiafava-Bignami Disease

Ken Johkura^a, Makoto Naito^a and Takayuki Naka^b

^a Department of Neurology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan
^b Division of Radiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan

Address correspondence to Ken Johkura, MD, PhD, Department of Neurology, Hiratsuka Kyosai Hospital, 9-11 Oiwake, Hiratsuka 254-8502, Kanagawa, Japan

Summary: Marchiafava-Bignami disease (MBD), a rare complication of chronic alcoholism, is characterized by primary demyelination of the corpus callosum. We report two cases of MBD in which fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging studies revealed symmetrical hyperintense lesions in the cerebral cortex (particularly in the lateral-frontal regions) in addition to the callosal lesions, which suggests an association of diffuse cortical lesions such as Morel’s laminar sclerosis with MBD.

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