Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sakamoto, S. Articles by Mori, E. Search for Related Content PubMed PubMed Citation Articles by Sakamoto, S. Articles by Mori, E.

American Journal of Neuroradiology 26:843-847, April 2005
© 2005 American Society of Neuroradiology

BRAIN

Detectability of Hypometabolic Regions in Mild Alzheimer Disease: Function of Time after the Injection of 2-[Fluorine 18]-Fluoro-2-Deoxy-D-Glucose

Setsu Sakamoto^a,b, Kazunari Ishii^a, Kayo Hosaka^a,c, Tetsuya Mori^a, Masahiro Sasaki^a,d and Etsuro Mori^a

^a Departments of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, Himeji
^b Division of Image-Based Medicine, Institute of Biomedical Research and Innovation, Kobe
^c Department of Radiology, Kobe University School of Medicine, Japan
^d PET Center, Himeji Central Hospital, Hyogo, Japan

Address reprint request to Dr Kazunari Ishii, Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, 520 Saisho-Ko, Himeji, Hyogo 670-0981, Japan

BACKGROUND AND PURPOSE: 2-[Fluorine 18]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) has played an important role in detecting hypometabolic regions in the brains of patients with dementia. To our knowledge, the optimal imaging time for dementia has not been investigated. The aim of this study was to evaluate the sensitivity of the early scanning (ES) compared with late scanning (LS) for demonstrating decreased regional glucose metabolism in patients with Alzheimer disease (AD).

METHODS: Twenty patients with mild AD (mean age ± standard deviation, 64.8 ± 5.2 years) and 20 age- and sex-matched healthy volunteers (age, 65.9 ± 4.5 years) were underwent FDG PET. Their cerebral glucose metabolic images were obtained on ES at 30–42 minutes and LS at 60–72 minutes after the administration of FDG 185–346 MBq. We compared regional cerebral metabolic images in a voxel-by-voxel analysis with statistical parametric mapping between patients with AD and control subjects and evaluated the difference in the hypometabolic regions between the two scans.

RESULTS: In the AD-to-healthy comparison, LS at the P < .001 level of significance showed more extensive and significant hypometabolic areas than did ES.

CONCLUSION: These results indicate that LS is superior to ES in detecting hypometabolic regions in patients with AD. For patients with AD, emission scanning soon after the administration of FDG is probably not advised.

This article has been cited by other articles:

				K. Ishii Advantage of Late Scanning in Brain 18F-FDG PET J. Nucl. Med., April 1, 2006; 47(4): 729 - 729. [Full Text] [PDF]

				I. Matsunari and W.-P. Chen Reply: Advantage of Late Scanning in Brain 18F-FDG PET. J. Nucl. Med., April 1, 2006; 47(4): 729a - 729a. [Full Text] [PDF]